Mutations
Mutations are the Blood and Wine character development system. They unlock through the secondary quest Turn and Face the Strange, which starts with a letter after the main quest Blood Run. The quest leads to Professor Moreau's hidden laboratory. Only one mutation can be active at a time.
How It Works
Each mutation is researched with skill points plus Greater red, green or blue mutagens. Mutations sit in connected tiers, and researching one opens the ones linked to it. A Potion of Restoration refunds the skill points spent on mutations, while the mutagens stay spent. Mutations are color-coded by tree: red Combat, blue Signs and green Alchemy. Some combine two or all three colors.
Extra Skill Slots
Strengthened Synapses is always active. It opens an extra skill slot after 2, 4, 8 and 12 researched mutations. These slots take skills that match the active mutation's colors.
Mutation List
| Mutation | Tree | Effect |
|---|---|---|
| Toxic Blood | Alchemy | Melee attackers take 1.5% of the damage dealt per point of Toxicity |
| Euphoria | Alchemy | +0.75% sword damage and sign intensity per point of Toxicity |
| Mutated Skin | Alchemy, Combat | Each Adrenaline Point cuts damage taken by 15%, up to 45% |
| Cat Eyes | Alchemy, Combat | Big crossbow damage boost and +50% crossbow crit chance |
| Metamorphosis | All three | Critical effects trigger a random decoction for 120 s at no Toxicity cost, up to 3 |
| Deadly Counter | - | +25% sword damage against monsters and counter-immune humans |
| Bloodbath | Combat | +5% attack power per melee blow, up to 250%, lost when hit |
| Adrenaline Rush | Combat, Signs | +30% sword attack power and sign intensity per foe after the first, for 30 s |
| Second Life | All three | At 0 Vitality, brief invulnerability and full Vitality, once per 180 s |
| Magic Sensibilities | Signs | Signs can crit, and Sign crit kills explode |
| Piercing Cold | Signs | Aard gets a 25% freeze chance, and frozen, knocked-down foes die |
| Conductors of Magic | Combat, Signs | Sign damage +50% of the drawn sword's damage |
All Mechanics
| Group | Pages |
|---|---|
| Signs | Signs, Aard, Igni, Yrden, Quen, Axii, Sign Intensity |
| Stats | Attack Power, Critical Hits, Armor Piercing, Adrenaline Points, Vitality, Stamina, Toxicity, Experience, Resistances, Damage Types and Effects |
| Skills and Mutations | Skills, Combat Skills, Cat School Techniques, Griffin School Techniques, Bear School Techniques, Mutagens, Mutations, Cat Eyes |
| Other Systems | Combat, Witcher Senses, Gwent, Reforge |
All Categories
